硫酸锌对肠系膜上动脉闭塞性休克后肺损伤的治疗作用

目的：探讨硫酸锌对肠系膜上动脉闭塞性（SMAO）休克后肺损伤的治疗作用及其机制。方法：行腹部手术分离出肠系膜上动脉并夹闭,2h后松夹,复制家兔SMAO休克模型。检测给与硫酸锌后SMAO休克家兔血浆及红细胞膜丙二醛（MDA）、红细胞超氧化物歧化酶（SOD）、血浆黄嘌呤氧化酶（XOD）含量;同时检测肺组织MDA、SOD和肺表面活性物质（PS）的含量,并观察小肠和肺的病理改变。结果：硫酸锌可使MDA及XOD含量降低,且可防止SOD和PS减少,避免了SMAO休克后肺损伤的进行性加剧。结论：SMAO休克并发急性肺损伤与组织氧化过程代谢紊乱有关,硫酸锌通过其稳膜作用能减轻或在一定程度上防止休克后肺损伤的发生和发展。

Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock

Aim: To study preventive and therapeutic effect of zinc sulfate on lun g injury during superior mesenteric artery occlusion (SMAO) shock and their mecha nism of action. Methods: Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde(MDA) in erythrocyte membrane a nd plasma, oxidase(XOD) in plasma, superoxide dismutase(SOD) in erythrocyte an d MDA, SOD and pulmonary surfactant(PS) in lung tissues homogenate were obser ved. Results: The administration of zinc sulfate decreased MDA and X OD, prevented the reduction of SOD and PS, and alleviated lung injury. Con clusion: It is suggested that lung is injuryed during SMAO shock and zi nc sulfate possesses preventive and therapeutic effect, through stabilized membr ane.