| FGF-1及其突变体的研究进展 |
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| 引用本文： | 刘华伟,赵勇,李贵生,李校堃. FGF-1及其突变体的研究进展[J]. 中国生物工程杂志, 2005, 25(8): 1-5 |
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| 作者姓名： | 刘华伟 赵勇 李贵生 李校堃 |
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| 作者单位： | 1. 暨南大学医药研发中心, 广州 510632;2. 中国科学院动物研究所生物膜与膜生物工程国家重点实验室 北京 100080 |
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| 基金项目： | 国家“863”计划资助项目(2001AA215030,2001AA215131,2002AA2Z3318) |
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| 摘 要： | 酸性成纤维细胞生长因子(acid fibroblastgrowth factor,FGF-1)是成纤维细胞生长因子家族重要的成员之一。来源于三个胚层的细胞都能够表达FGF-1,其生物学效应非常广泛,在组织和器官发育、血管发生、血细胞生成、肿瘤发生和伤口愈合等方面发挥着重要作用。FGF-1不但可以在细胞外通过胞内信号通路而且也可以进入细胞内部发挥生物学功能。主要综述FGF-1信号转导方面的研究进展、促细胞增殖作用的可能分子机制以及将来的临床应用前景。
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| 关 键 词： | 酸性成纤维细胞生长因子 增殖 突变 信号转导 |
| 收稿时间： | 2005-01-05 |
| 修稿时间： | 2005-04-13 |
Advance on Wild and Modified Acid Fibroblast Growth Factor |
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| LIU Hua-wei,ZHAO Yong,LI Gui-sheng,LI Xiao-kun. Advance on Wild and Modified Acid Fibroblast Growth Factor[J]. China Biotechnology, 2005, 25(8): 1-5 |
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| Authors: | LIU Hua-wei ZHAO Yong LI Gui-sheng LI Xiao-kun |
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| Affiliation: | LIU Hua-wei~1,2 ZHAO Yong~2 LI Gui-sheng~1 LI Xiao- kun~1 |
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| Abstract: | Acid fibroblast growth factor(FGF-1) is a 17 - 18 kDa nonglycosylated polypeptide that expresses on a variety of cells from all three germ layers. It is a member of FGFs and has extensive biological function s in organ and tissue development, angiogenesis, hematopoiesis, tumorigenesis an d wound healing. Mitogenic induction by FGFs begins with the interaction of FGFR . FGF-1 not only interacts with the FGFRs on cell membrane, but also enters the cell to play its biological functions. The advance of FGF-1 signaling transduc tion, the possible molecular mechanism and the potential clinical application of aFGF were reviewed mainly. |
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| Keywords: | Acid fibroblast growth factor Proliferation Mut ation Signaling transduction |
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