Hydrocortisone inhibits prostaglandin production but not arachidonic acid release from cultured macrophages |
| |
Authors: | J N Wood P R Coote J Rhodes |
| |
Institution: | Department of Experimental Immunobiology, The Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, England |
| |
Abstract: | We have investigated the action of hydrocortisosone on arachidonic acid mobilisation in cultures of mouse peritoneal macrophages, mouse L929 cells and the mouse macrophage-like cell line RAW264. Hydrocortisone inhibits both arachidonic acid release and prostaglandin production by L929 cells. However, prostaglandin production by macrophages or RAW264 cells is inhibited with a concomitant stimulation rather than inhibition of arachidonic acid release. These data suggest that hydrocortisone acts at the level of phospholipase activity in fibroblasts but at a later stage of prostanoid production in macrophages. |
| |
Keywords: | Glucocorticoid steroid Macrophage Prostaglandin |
本文献已被 ScienceDirect PubMed 等数据库收录! |