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MiR-29b Protects Dorsal Root Ganglia Neurons from Diabetic Rat |
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| Authors: | Xiaona Zhang Xu Gong Shuhai Han Yang Zhang |
| Institution: | 1. Department of Anesthesiology, The First Affiliated Hospital of Jilin University, 71 Xinmin Avenue, Changchun, Jilin, China 2. Department of Hand and Podiatric Surgery, The First Affiliated Hospital of Jilin, University, 71 Xinmin Avenue, Changchun, Jilin, China 3. Department of Neurosurgery, The First Affiliated Hospital of Jilin University, 71 Xinmin Avenue, Changchun, Jilin, China |
| Abstract: | Accumulated evidences implicated that microRNAs may be involved in diabetic neuropathy. Here, we investigated miR-29’s roles in primary isolated dorsal root ganglion (DRG) neurons from STZ-induced diabetic rats. First, miR-29b was found down-regulated after STZ-injection. Inhibitions were increased with time course. Down-regulation of miR-29b was associated with higher apoptosis rate and more serious axonal swelling. Meanwhile, axonogeneration genes were inhibited, whereas neurodegenerative genes were stimulated. Restoration of miR-29b by mimic experiment could reverse the above neuropathy. Furthermore, western blot analysis disclosed that miR-29b could abolish Smad3 activation. In conclusion, the present study identifies that miR-29b could protect DRG from diabetic rats. This protective effects suggested potential therapeutic application of miR-29b in diabetic neuropathy. |
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