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Populational polymorphisms in silver staining of nucleolus organizer regions (NORs) in human acrocentric chromosomes
Authors:A. -V. Mikelsaar  T. Ilus
Affiliation:(1) Laboratory of Genetics and Molecular Cytology, Institute of General and Molecular Pathology, Tartu State University, Burdenkostr. 34;(2) Laboratory of Medical Genetics of Tartu Clinical Hospital, 202400 Tartu, Estonian SSR, Russia
Abstract:Summary The Ag stainability of the nucleolus organizer region (NOR) was studied in the acrocentric chromosomes identified by Q banding of cultured lymphocytes in 41 karyotypically normal persons (33 males and 8 females) originating from southeast Estonia. The data obtained are compared with those established earlier for a combined Vienna-Ulm population of 51 karyotypically normal persons (see Mikelsaar et al., 1977a). Significant differences between the two populations in the frequency and patterns of Ag-positive NORs were found. The following findings were most striking: the frequency of Ag-positive NORs in chromosome 14 and in the totals was significantly lower in the Estonian population than in the Vienna-Ulm population (P<0.01). The average modal number of Ag-positive NORs per individual was 7.8 in the Estonian population and 8.7 in the Vienna-Ulm sample (P<0.01). If the data of the two populations were combined the frequency of positive NORs was significantly (P<0.05) lower in chromosome 22 than in 13,15, and 21, but not 14.
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