Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation |
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| Authors: | H Benda S Panzer V Kiefel C Mannhalter W Hinterberger K Lechner C Mueller-Eckhardt |
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| Institution: | Division of Hematology and Blood Coagulation, University of Vienna, Austria. |
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| Abstract: | We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions. |
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