RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage |
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Authors: | Park Seon Ho Kim Jung Jin Chung Jin Sil Lee So Ra Lee Gi Young Kim Hyung Jung Yoo Young Do |
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Institution: | aCenter for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA;bDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA;cDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL, USA |
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Abstract: | Dendritic cells are the most potent antigen presenting cells responsible for the development of immune responses in cancer. However, it is known that the function of dendritic cells in tumor-bearing hosts is severely compromised. Our previous studies demonstrated that the defects in dendritic cell function are due, to a large extent, to the accumulation of high amounts of lipids – predominantly triglycerides – in a substantial proportion of dendritic cells in tumor-bearing mice and patients with cancer. The dendritic cells accumulation of lipids is likely associated with their up-regulation of a scavenger receptor A. This receptor is primarily responsible for uptake of modified lipids. Here, by using different versions of liquid chromatography–mass spectrometry, we identified several molecular species of oxygenated lipids in plasma of tumor-bearing animals that may be responsible for their uptake and accumulation by dendritic cells via scavenger receptor A-dependent pathway – the effect that may be associated with the loss of dendritic cell’s immune surveillance function in cancer. |
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Keywords: | Cancer Tumor-bearing mice Plasma Dendritic cells Scavenger receptor A Lipid uptake Oxygenated fatty acids |
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