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Effect of picrotoxinin on benzodiazepine receptor binding
Authors:Andrew Y Chweh  Rafael A Ulloque  Ewart A Swinyard  Harold H Wolf
Institution:(1) Department of Biochemical Pharmacology and Toxicology College of Pharmacy, University of Utah, 84112 Salt Lake City, Utah
Abstract:The effect of picrotoxinin on 3H]flunitrazepam binding to benzodiazepine receptors was investigated. In mouse forebrain membranes, picrotoxinin inhibited basal, GABA- and pentobarbital-stimulated 3H]flunitrazepam binding; this inhibitory activity was temperature- and chloride ion-dependent. Scatchard analysis of the data indicates that picrotoxinin decreases the number of binding sites without alterating binding affinity. In cerebellar membranes, picrotoxinin did not alter 3H]flunitrazepam receptor binding.
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