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Monkey hybrid stem cells develop cellular features of Huntington's disease |
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| Authors: | Chuti Laowtammathron Eric CH Cheng Pei-Hsun Cheng Brooke R Snyder Shang-Hsun Yang Zach Johnson Chanchao Lorthongpanich Hung-Chih Kuo Rangsun Parnpai Anthony WS Chan |
| Affiliation: | (1) Yerkes National Primate Research Center, 954 Gatewood Rd, NE Atlanta, GA 39329, USA;(2) Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, GA 30322, USA;(3) Embryo Technology and Stem Cell Research Center, School of Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand;(4) Stem Cell Program, Institute of Cellular and Organismic Biology and Genomics Research Center, Academia Sinica, Taipei, Taiwan |
| Abstract: | BackgroundPluripotent stem cells that are capable of differentiating into different cell types and develop robust hallmark cellular features are useful tools for clarifying the impact of developmental events on neurodegenerative diseases such as Huntington's disease. Additionally, a Huntington's cell model that develops robust pathological features of Huntington's disease would be valuable for drug discovery research. |
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