Pectin-Based Bioadhesive Delivery of Carbenoxolone Sodium for Aphthous Ulcers in Oral Cavity |
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Authors: | Nathaya Wattanakorn Panida Asavapichayont Jurairat Nunthanid Sontaya Limmatvapirat Srisagul Sungthongjeen Doungdaw Chantasart Pornsak Sriamornsak |
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Institution: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand;(2) Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand;(3) Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand;(4) Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand; |
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Abstract: | The objective of this study was to prepare and evaluate the pectin-based dosage form for buccal adhesion. Carbenoxolone sodium,
which is used for the treatment of aphthous ulcers in oral cavity, was used as a model drug. The pectin buccal discs were
prepared by direct compression. The water uptake and erosion of pectin disc increased progressively with the swelling time.
The bioadhesion of dried pectin discs decreased when either the discs were hydrated or the buccal tissue was wet with a small
volume of medium. The influencing factors such as pectin type, pectin to lactose ratio, and sweetener type on the formulations
were investigated. The results demonstrated that buccal discs prepared from pectin with a high degree of esterification (DE)
showed a weaker and more friable characteristic than that with low DE. Decreasing pectin to lactose ratio resulted in the
high dissolution rate with low bioadhesive properties. Addition of sweetener in the formulations also affected the hardness,
friability, and bioadhesive properties of the discs. The pectin discs containing sweetening agent showed a higher drug release
than those without sweetener. The results suggested that pectin-based bioadhesive discs could be used to deliver carbenoxolone
sodium in oral cavity. |
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