Passive avoidance deficit following intracerebroventricular administration of cholecystokinin tetrapeptide amide in rats |
| |
Authors: | G Katsuura S Itoh |
| |
Institution: | Shionogi Research Laboratories, Fukushima-ku, Osaka 553, Japan |
| |
Abstract: | The effect of cholecystokinin tetrapeptide amide (CCK-4) injected into the lateral cerebral ventricle on memory processes was examined by a one-trial passive avoidance test in the rat. CCK-4 injection 30 and 60 min before the first retention test caused a shortened latency to response, and its chronic infusion into the lateral ventricle at a rate of 2 micrograms/day shortened the latency of the response to the level of almost complete amnesia. CCK-4 also reduced arginine-vasopressin effect on memory processes when administered simultaneously 30 min before the first retention test, but its amnestic action is short-lasting and antagonized by relatively small amounts of cholecystokinin octapeptide (CCK-8). In addition, the shortened latency to response was admitted to be not always associated with the motility effect of CCK-4. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|