A dominant mutation in the gene for the Nag repressor of Escherichia coli that renders the nag regulon uninducible. |
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Authors: | J A Plumbridge |
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Affiliation: | Institut de Biologie Physico-chimique (URA1139), Paris, France. |
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Abstract: | The gene nagC encodes the repressor for the nag regulon. A point mutation within the gene, which confers a super-repressor phenotype and makes the repressor insensitive to the inducer, N-acetylglucosamine 6-phosphate, has been characterized. The mutation is semi-dominant since heterozygous diploids have reduced growth rates on glucosamine and N-acetylglucosamine compared to the wild-type strain. |
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