Cytotoxic and mutagenic effects of emodin on cultured mouse carcinoma FM3A cells |
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| Authors: | H Morita M Umeda T Masuda Y Ueno |
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| Affiliation: | Kihara Institute for Biological Research, Yokohama City University, Japan. |
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| Abstract: | Employing a suspension culture of a mouse mammary carcinoma cell line, FM3A cells, the cytotoxicity and induced mutagenicity of emodin (EM) were examined and compared with those of 2-hydroxy-emodin (2-OH-EM), which was identified as an active form of EM in the Ames/microsomes assay. EM was cytotoxic to FM3A cells in concentrations of 1-10 micrograms/ml, and induced 6-thioguanine-resistant (6TGr) mutation. 2-OH-EM was a little more toxic than EM, but induced little mutation. |
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