Microprecipitation test for the detection of adenovirus antibody |
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| Authors: | N H Levitt K R Amsler R W McKinney D M Robinson |
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| Institution: | 1. U. S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701, USA;2. Microbiological Associates, Inc. Bethesda, Maryland 20014, USA |
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| Abstract: | A microprecipitation test (MPT) for the detection of adenovirus antibody has been developed. The new procedure combines precipitation of virus particles with specific antibody, separation of unreacted components from the resulting electroneutral virus-antibody complexes by electrophoresis, and detection of these complexes with a protein stain. Type-specific antibody was detected in rabbit antisera but, under similar conditions, antibody in convalescent human sera reacted with adnovirus antigens of types 4 and 7. Paired sera from 57 patients with suspected adenovirus infection were examined for significant rises in antibody activity by the microprecipitation test and by complement fixation. |
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