Evidence for palindromic sequences near the termini of adenovirus 2 DNA |
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Authors: | R Padmanabhan Raji Padmanabhan Maurice Green |
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Institution: | Institute for Molecular Virology Saint Louis University School of Medicine 3681 Park Avenue St. Louis, Missouri 63110 USA |
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Abstract: | When the kinetics of exonuclease III digestion of adenovirus 2 DNA were studied by DNA polymerase I-catalyzed repair synthesis at 5°C, there was an indication of the formation of hairpin structure in the single-stranded template, exposed by exonuclease III. The hairpin structure results from a sequence with an inverted repetition of the type, a b c d···d′ c′ b′ a′. The location of these sequences was determined to be about 180 nucleotides from each terminus of adenovirus 2 DNA with the use of specific restriction endonucleases. The possible role of this region in the replication of the adenovirus 2 genome is discussed. |
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