Jejunal and ileal d-glucose transport in isolated brush border membranes |
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| Authors: | Ulrich Hopfer Kristine Segrist-Nelson Rhea Groseclose |
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| Affiliation: | 1. Department of Anatomy, School of Medicine, and Developmental Biology Center, Case Western Reserve University, Cleveland, Ohio, 44106 U.S.A.;2. Laboratory for Biochemistry, Federal Institute of Technology, Zurich Switzerland |
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| Abstract: | d-Glucose transport was investigated in isolated brush border membranes from small intestine. The transport properties of membranes from upper jejunum were compared with those from terminal ileum. The jejunal membranes accumulated d-glucose to a greater extent than the ileal membranes when supplied with energy in the form of a NASCN gradient. This difference is behavior is similar to that of the more intact epithelial preparations and suggests that the isolated membranes actually reflect the state present in intact cells. Ileal membranes transported d-glucose about two to three times slower than the jejunal ones, which can partially explain the lower sugar accumulation. |
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| Keywords: | To whom correspondence should be addressed at the Department of Anatomy Case Western Reserve University Cleveland Ohio 44106 U.S.A. |
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