Affiliation: | 1.Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences,Kagoshima University,Kagoshima,Japan;2.The Near-Future Locomotor Organ Medicine Creation Course (Kusunoki Kai), Graduate School of Medical and Dental Sciences,Kagoshima University,Kagoshima,Japan;3.Center for Rheumatic Diseases,Japanese Red Cross Kagoshima Hospital,Kagoshima,Japan;4.Department of Hematology and Immunology, Graduate School of Medical and Dental Sciences,Kagoshima University,Kagoshima,Japan;5.Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences,Kagoshima University,Kagoshima,Japan;6.Department of Orthopaedic Surgery,Japanese Red Cross Kagoshima Hospital,Kagoshima,Japan |
Abstract: | ObjectiveOsteoporosis is a complication of rheumatoid arthritis. We examined the risk factors for bone loss in rheumatoid arthritis patients receiving biological disease-modifying anti-rheumatic drugs. Lumbar spine and femoral neck bone mineral density was measured at two time points in 153 patients with rheumatoid arthritis managed with biological disease-modifying anti-rheumatic drugs. We examined patients’ variables to identify risk factors for least significant reduction of bone mineral density.ResultsLeast significant reduction of lumbar spine bone mineral density (≤ ? 2.4%) was seen in 13.1% of patients. Least significant reduction of femoral neck bone mineral density (≤ ? 1.9%) was seen in 34.0% of patients. Multiple logistic regression analysis showed that a risk factor for least significant reduction of the lumbar spine was high-dose methylprednisolone use. Multiple regression analysis showed that a risk factor for least significant reduction of the femoral neck was short disease duration. Our findings showed that a risk factor for femoral neck bone mineral density reduction was a short disease duration. These findings suggest that rheumatoid arthritis patients receiving treatment with biological disease-modifying anti-rheumatic drugs may benefit from earlier osteoporosis treatments to prevent femoral neck bone loss. |