Microchromatography of hemoglobins : VII. Detection of some uncommon hemoglobin variants and two rapid methods for the quantitation of Hb-A2 in the presence of Hb-C |
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| Authors: | EC Abraham THJ Huisman WA Schroeder Laurence A Pace Lana Grussing |
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| Institution: | Laboratory of Protein Chemistry and Sickle Cell Center, Medical College of Georgia, Augusta, Ga. 30902 U.S.A.;Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, Calif. 91125 U.S.A. |
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| Abstract: | Microchromatographic procedures on columns of DEAE- or CM-cellulose are described for the separation of the more common abnormal hemoglobins S and C from other, often uncommon, variants such as J, N, I, K-Woolwich, Hope, D, E, O, and Deer Lodge. Two procedures on conventionally sized columns of CM-cellulose permit the quantitative determination of Hb-A2 in the presence of Hb-C in a day. |
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