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The fusion of abnormal plasma lipoprotein (LP-X) and the erythrocyte membrane in patients with cholestasis studied by electronmicroscopy |
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| Authors: | A.J. Verkleij I.L.D. Nauta J.M. Werre J.G. Mandersloot B. Reinders P.H.J.Th. Ververgaert J. de Gier |
| Affiliation: | 1. Institute of Molecular Biology, State University of Utrecht, The Netherlands;2. Laboratory of Biochemistry, State University of Utrecht, The Netherlands;3. Biological Ultrastructural Research Unit, State University of Utrecht, The Netherlands;4. Department of Internal Medicine, Municipal Hospital, Arnhem The Netherlands |
| Abstract: | Adhesion followed by fusion of LP-X vesicles with the erythrocyte membrane is an important contribution to the erythrocyte enlargement in patients with intra or extra hepatic cholestasis. Adhesion of LP-X vesicles is demonstrated by thin section and freeze-etch electronmicroscopy. Fusion of LP-X with the erythrocyte membrane is deduced from biochemical data and freeze-etch electronmicroscopy in that the uptake of cholesterol and lecithin coincides with the increase in smoooth areas on the fracture faces of the erythrocyte membrane. |
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