Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells |
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Authors: | Heinrich Betz |
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Institution: | 1. Biochemisches Institut der Universität Freiburg i.Br. Freiburg, Federal Republic of Germany;2. Institut für Biochemie der Gesellschaft für Strahlen- und Umweltforschung, Freiburg, Federal Republic of Germany |
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Abstract: | In exponentially growing cells of Saccharomyces cerevisiae, cycloheximide stimulated intracellular protein degradation to the same extent as did starvation for required amino acids. By using inhibitors of macromolecular synthesis and temperature-sensitive mutants defective in different steps of RNA and protein synthesis it could be demonstrated, that this stimulation of protein degradation was directly related to the inhibition of protein synthesis per se, but not connected to the cessation of ribosomal RNA synthesis or to the inhibition of cell growth. |
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