Interactions of the cholesterol side-chain with egg lecithin a spin label study |
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Authors: | K.E Suckling G.S Boyd |
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Affiliation: | Department of Biochemistry, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG U.K. |
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Abstract: | The effect in egg lecithin liposomes of cholesterol and cholesterol analogues with side-chains of reduced length on the order parameters of two steroid spin labels has been studied. Analogoues with side-chains shorter than cholesterol by more than three carbons cause significantly less ordering than cholesterol. Liposomes containing a cholesterol analogue in which the side-chain is absent cause very little increase in the ordering of a new sterol spin label in which the nitroxide is incorporated into the side-chain. The results suggest that the sterol side-chain exerts a great influence on membrane rigidity within its immediate environment. |
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Keywords: | 3NC 25NC |
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