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Effect of hemin and isonicotinic acid hydrazide on the uptake of iron from transferrin by isolated rat liver mitochonodria |
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| Authors: | M.E. Koller P.H. Prante R. Ulvik I. Romslo |
| Affiliation: | Laboratory of Clinical Biochemistry, 5016 Haukeland sykehus, Bergen, Norway |
| Abstract: | Isolated rat liver mitochondria accumulate iron from the suspending medium when [59Fe] transferrin is used as a model compound. The accumulation proceeds by two different mechanisms, i.e. by an energy-dependent and an energy-independent mechanism. The energy-dependent uptake of iron from transferrin is inhibited by hemin and stimulated by isonicotinic acid hydrazide. The energy-independent uptake of [59Fe] transferrin is influenced neither by hemin nor by isonicotinic acid hydrazide. |
| Keywords: | ALA-synthetase δ-aminolaevulinic acid synthetase HEPES N-2-hydroxyethyl-piperazine-N′-2-ethanesulphonic acid INH isonicotinic acid hydrazide CCCP carbonyl cyanide PIPES piperazine-N,N′-2-bis(2-ethanesulphonic acid) |
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