Conversion of proalbumin into serum albumin in the secretory vesicles of rat liver |
| |
| Authors: | Yukio Ikehara Kimimitsu Oda Keitaro Kato |
| |
| Affiliation: | Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences Kyushu University, Fukuoka 812, Japan |
| |
| Abstract: | The conversion site of proalbumin into serum albumin was investigated in the subcellular fractions of rat liver labeled with [3H] leucine in vivo. In the cisternae-rich fraction of the Golgi complex as well as in the microsomal fraction most of the labeled albumin was detected as proalbumin, while in the secretory vesicles, which were obtained in increased amount by oral administration of ethanol, more than 70% of the labeled albumin was found as serum type, indicating that conversion of proalbumin into serum albumin occurs within the secretory vesicles in rat liver. Little accumulation of albumin was observed in colchicine-treated rats. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
