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A human enzyme that liberates uracil from DNA |
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| Authors: | Mutsuo Sekiguchi Hiroshi Hayakawa Fumiko Makino Kiyoji Tanaka Yoshio Okada |
| Affiliation: | 1. Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan;2. National Cancer Center Research Institute, Tokyo 104 Japan;3. Research Institute for Microbial Diseases, Osaka University, Osaka 565 Japan. |
| Abstract: | An enzyme activity which acts specifically on uracil-containing DNA was found in human placenta and cultured fibroblasts. The enzyme liberates uracil from DNA in the presence of EDTA at pH 7.5. Almost equal levels of the activity were found in normal and xeroderma pigmentosum cell lines (complementation group A). |
| Keywords: | XP xeroderma pigmentosum |
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