R-factor-mediated resistance to tetracycline in K12: An R-factor with a mutation to temperature-sensitive tetracycline resistance |
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Authors: | T.W. Young S.J. Hubball |
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Affiliation: | 2. Department of Biochemistry. The University of Birmingham, P.O. Box 363, Birmingham B15 2TT UK.;1. Department of Genetics. The University of Birmingham, P.O. Box 363, Birmingham B15 2TT UK. |
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Abstract: | R-factor-mediated resistance to tetracycline was studied in K12 carrying an F-like R-factor which has a mutation resulting in temperature-sensitive resistance to the drug. The rate of uptake of tetracycline in this mutant is sensitive to temperature, but the rate of efflux is not. These results are consistent with the view that resistance to tetracycline is expressed at the level of the influx rather than of the efflux of tetracycline. |
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