Nd:YAG激光治疗特殊部位尖锐湿疣的疗效观察

目的：观察Nd：YAG激光治疗位于尿道口、阴道口、肛门及肛周的难治性尖锐湿疣的疗效。方法：将61例特殊部位的尖锐湿疣的患者随机分为实验组（31例）和对照组（30例），实验组采用Nd：YAG激光机治疗，对照组采用普通CO2激光治疗机，随访半年观察两组的创面愈合情况、治愈率及复发率。结果：采用Nd：YAG激光治疗的实验组一次治愈率为80．64％，高于对照组的一次治愈率56．67％（x^2=4．087，P〈0．05），但两组的总治愈率无显著性差异（x^2=1．198，P〉0．05）。实验组复发率为22．58％，低于对照组的复发率46．67％。两者有显著性差异（x^2=3．918，P〈0．05）。激光术后第5天实验组的愈合率45．16％高于对照组的愈合率20．00％，两者有显著性差异（x^2=4．380，P〈0．05）；第7天实验组的愈合率为87．09％高于对照组的愈合率60．00％，两者有显著性差别（x^2=4．469，P〈0．05）；第10天实验组的患者全部愈合，愈合率为100％，高于对照组的愈合率83．33％（P=0．024〈0．05）。结论：Nd：YAG激光治疗特殊部位尖锐湿疣效果好，创面愈合快，复发率低。

Analysis of Therapeutic Effect of Condyloma Acuminatum in Privileged Sites Treated with Nd:YAG Laser

Objective: To observe the therapeutic effect of recalcitrant condyloma acuminatum in urethral orifice,ostium vaginae,anus and crissum treated with Nd:YAG laser.Methods: 61 patients with condyloma acuminatum in privileged sites were divided into experimental group and control group in random.Experimental group was 31 patients treated with Nd:YAG laser,while control group was 30 patients treated with CO_2 laser.Follow up a case by regular visits to half a year and observe two groups of the healing state of raw surface,cure rate and recurrence rate.Results: The cure rate was 80.64% after experimental group was treated with Nd:YAG laser once.It was higher than that of control group,56.67 %(x~2=4.087,P <0.05).But no difference could be found in the con-cure rate of two groups(x~2=1.198,P >0.05).The recurrence rate in experimental group was 22.58 %,which was lower than that in control group,46.67 %.There was remarkable difference between two groups(x~2=3.918,P <0.05).Five days after the laser treatment,the healing rate of raw surface in experimental group was 45.16 %,which was higher than that in control group,20.00 %(x~2=4.380,P <0.05).Seven days after the treatment,the healing rate in experimental group,87.09 % was higher than that in control group,60.00 %(x~2=4.469,P <0.05).The healing rate in experimental group was 100% in ten days after the laser treatment,while the healing rate in control group was 83.33 %.There was marked qualitative difference between the two groups(P =0.024<0.05).Conclusion:Nd:YAG laser had proven to be safe and effective in treating condyloma acuminatum located in raw surface.The raw surface heal fast after laser treatment and the recurrence rate was low.