The role of Irf6 in tooth epithelial invagination |
| |
Authors: | Blackburn James Ohazama Atsushi Kawasaki Katsushige Otsuka-Tanaka Yoko Liu Bigang Honda Kenya Rountree Ryan B Hu Yinling Kawasaki Maiko Birchmeier Walter Schmidt-Ullrich Ruth Kinoshita Akira Schutte Brian C Hammond Nigel L Dixon Michael J Sharpe Paul T |
| |
Institution: | Department of Craniofacial Development and Comprehensive Biomedical Research Centre, Dental Institute, King's College London, UK. |
| |
Abstract: | Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|