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Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1) |
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| Authors: | Harikrishnan Lalgudi S Srivastava Neelam Kayser Lauren E Nirschl David S Kumaragurubaran K Roy Amrita Gupta Anuradha Karmakar Sukhen Karatt Tajudheen Mathur Arvind Burford Neil T Chen Jing Kong Yan Cvijic MaryEllen Cooper Christopher B Poss Michael A Trainor George L Wong Tai W |
| Institution: | Early Discovery Chemistry, Bristol-Myers Squibb Co., Princeton, NJ 08543-4000, USA. lalgudi.harikrishnan@bms.com |
| Abstract: | Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemical series are described. |
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