QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides) |
| |
Authors: | Mekapati S B Denny W A Kurup A Hansch C |
| |
Affiliation: | Department of Chemistry, Pomona College, Claremont, CA 91711, USA. |
| |
Abstract: | QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells. This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|