Induction of Transcription Factor A-myb Expression in Reactive Astrocytes Following an Excitotoxic Lesion in the Mouse Hippocampus |
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Authors: | Gye Sun Jeon Hee Jine Byun Sung Kyung Park Sang Wook Park Dong Woon Kim Je Hoon Seo Choong Ik Cha Sa Sun Cho |
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Affiliation: | Department of Anatomy, Seoul National University College of Medicine, Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea. |
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Abstract: | In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions. |
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Keywords: | A-myb Reactive astrocytes Kainic acid Hippocampus |
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