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An endogenous inhibitor of erythrocyte membrane (Ca2+ + Mg2+)-ATPase.
Authors:K S Au
Affiliation:1. Department of Biological and Agricultural Engineering, Texas A&M University, College Station, TX, USA;2. School of Hydrology and Water Resources, Nanjing University of Information Science and Technology, Nanjing, China;1. FEMTO-ST Institute, UFC/CNRS/ENSMM/UTBM, Université Bourgogne Franche-Comté, Besançon, France;2. Laboratoire Chrono-Environnement, UMR CNRS/UFC, Université Bourgogne Franche-Comté, Montbéliard, France;3. Laboratoire de Chimie Agro-Industrielle (LCA), INP-ENSIACET, Toulouse, France;4. Laboratoire Génie de Production (LCP), Université de Toulouse-ENIT, Tarbes, France;5. InTechFibres Division, FCBA, Grenoble, France;6. Inovyn, Tavaux, France;1. Cabinet de dermatopathologie, 35, Av. Mathurin-Moreau, 75019 Paris, France;2. Service de dermatologie, hôpital Saint-Joseph, 185, Rue Raymond-Losserand, 75014 Paris, France;3. Service de dermatologie, hôpital Bichat, 46, rue Henri-Huchard, 75018 Paris, France;4. Cabinet médical, 4, rue du Maréchal Harispe, 75007 Paris, France
Abstract:
  • 1.1. An inhibitor of erythrocyte membrane (Ca2+ + Mg2+)-ATPase was isolated from pig haemolysate along with (Ca2+ + Mg2+-ATPase activator.
  • 2.2. The inhibitor also suppressed phosphodiesterase and adenylate cyclase activities.
  • 3.3. The inhibitor is relatively heat labile as compared with the activator.
  • 4.4. (Ca2+ + Mg2+-ATPase of stored erythrocyte membrane responded to the inhibitor but not to the activator.
  • 5.5. The inhibitor suppressed (Ca2+ + Mg2+)-ATPase activity of ethylene-diaminetetraacetic acid extracted but not of ethyleneglycol-bis-(β-aminoethyl ether)N.N'-tetraacetic acid extracted erythrocyte membrane. The activator stimulated (Ca2+ + Mg2+-ATPase of both types of membrane.
  • 6.6. Gel nitration on Sephadex revealed two inhibitor peaks of molecular weights 56.000 and 35.000 in contrast to 42.000 for the activator.
Keywords:
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