Production of Recombinant Endostatin in Milk of Transgenic Mice |
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| Authors: | Zavadskaya E S Zacharova E S Kadulin S G Kibardin A V Kiselev S L Gnuchev N V |
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| Institution: | (1) Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334, Russia;(2) Center of Medical Research, University of Oslo, Moscow, 117334, Russia |
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| Abstract: | Using the bovine  S1-casein gene, a genetic construct with an endostatin-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obtained. The mice secreted endostatin in milk at 70–300 ng/ l and transmitted this character to their progeny. |
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