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Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging |
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| Authors: | Sinha Tuhin K Khatib-Shahidi Sheerin Yankeelov Thomas E Mapara Khubaib Ehtesham Moneeb Cornett D Shannon Dawant Benoit M Caprioli Richard M Gore John C |
| Affiliation: | Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA. tk.sinha@vanderbilt.edu |
| Abstract: | We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging. |
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