Effect of the crude extract of Vernonia polyanthes Less. on blood pressure and renal sodium excretion in unanesthetized rats. |
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| Authors: | R Romanezi da Silveira M A Foglio J A R Gontijo |
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| Institution: | 1. Pharmacology Laboratory, Federal University of São João del-Rei, 35501-296 Divinópolis, Brazil;2. Pharmacognosy Laboratory, Federal University of São João del-Rei, 35501-296 Divinópolis, Brazil;3. Pharmacobotany and Medicinal Plants Laboratory, Federal University of São João del-Rei, 35501-296 Divinópolis, Brazil;4. Experimental Pathology Laboratory, Federal University of São João del-Rei, 35501-296 Divinópolis, Brazil;5. Molecular Biology Laboratory, Federal University of São João del-Rei, 35501-296 Divinópolis, Brazil;6. Department of Natural Sciences, Federal University of São João del-Rei, 36307-352, São João del-Rei, Brazil;7. Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, Brazil;8. Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM), Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, Brazil;1. CINDEFI (UNLP CONICET La Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina;2. Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany |
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| Abstract: | This study evaluated the effect of oral crude Vernonia polyanthes Less. hydroalcoholic extract administration (CHE, 0.5 and 1.0 g/kg body wt., daily for 7 days) on arterial blood pressure and renal sodium excretion in conscious rats. CHE administration decreased arterial blood pressure dose-dependently followed by a significant rise in creatinine clearance and a fall in fractional post-proximal sodium excretion was compared to the control group. These results suggest that blood pressure decrease induced by the oral crude Vernonia hydroalcoholic extract may be blunted by reduction of the post-proximal renal sodium excretion. Thus, the present study shows that Vernonia extract is a potential vasodilatation agent in normotensive rats without any effects on renal tubule autoregulation mechanisms. |
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