Sanguinarine, inhibitor of Na-K dependent ATP'ase. |
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| Authors: | K D Straub P Carver |
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| Institution: | Medical Research, Veterans Administration Hospital and Department of Medicine and Biochemistry, University of Arkansas School of Medicine, Little Rock, Arkansas 72201, USA |
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| Abstract: | Sanguinarine, a benzophenanthridine alkaloid, has been found to be an inhibitor of the Na+, K+-ATPase isolated from guinea pig brain. It has a pI50 of 5.25 (5.62 μM) and exhibits uncompetitive kinetics with respect to Na+] and K+] and is non-competitive with respect to ATP]. Preincubation with sanguinarine causes increased inhibition. ATP partially protects the enzyme against this preincubation effect, while Na+ protects to a lesser extent and K+ has no effect. |
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