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Mitogen-activated protein kinases and their role in regulation of cellular processes
Authors:Strnisková M  Barancík M  Ravingerová T
Institution:Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia. monika.strniskova@ncc.sk
Abstract:Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes connecting cell-surface receptors to critical regulatory targets within cells. The three major MAPK cascades are known, the extracellular signal-regulated protein kinase (ERK) cascade, c-Jun amino-terminal protein kinase/stress-activated protein kinase (JNK/SAPK) cascade and p38-MAPK cascade. This paper is focused on characterization of these MAPK cascades in terms of their distribution and biological role in some pathological processes (apoptosis, hypertrophy) with a special orientation on the role of MAPKs in cardiovascular system during ischemia/reperfusion.
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