Role of the Yes and Csk tyrosine kinases in the development of a pathological state in the human retina |
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Authors: | Lyudmila Baranova Valentina Emelyanova Igor Volotovski |
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Institution: | (1) Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Akademicheskaya str., 27, 220072 Minsk, Belarus |
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Abstract: | Amplification and a cloning of fragments of genes of human retina tyrosine kinases, the nucleotide sequences of which feature
a high homology to the gene families of the Yes and Csk tyrosine kinases, and a cloning of the complete coding sequence of
the cDNA of the Csk tyrosine kinase gene of the human lymphocytes have been carried out. It has been established that this
sequence contains 1,624 bp and encodes a protein that, with a 99% homology, corresponds to the human tyrosine kinase. A comparative
analysis of the nucleotide sequences of the full-size cDNA of the Csk tyrosine kinase of the lymphocytes of healthy donors
and of patients with an eye choroidal melanoma has shown that a risk of development of an eye choroidal melanoma can be estimated
by the frequency of occurrence of a mutant allele in the 10th exon. |
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Keywords: | |
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