Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay |
| |
| Authors: | H Babich E Borenfreund |
| |
| Institution: | Laboratory Animal Research Center, Rockefeller University, New York, New York 10021. |
| |
| Abstract: | The neutral red (NR) cell viability assay was used with various cell types of human origin to quantitate the potency of T-2 mycotoxin and its metabolites. The human melanoma SK-Mel/27 cell line was the most sensitive, with a midpoint cytotoxicity value of 2.8 ng of T-2 per ml. With the human hepatoma cell line, HepG2, the sequence of potency for a series of mycotoxins was T-2 greater than HT-2 greater than T-2 triol greater than T-2 tetraol. |
| |
| Keywords: | |
|
|
