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Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway |
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| Authors: | Xu Jianmin Walsh Stephanie B Verney Zoe M Kopelovich Levy Elmets Craig A Athar Mohammad |
| Affiliation: | aDepartment of Dermatology, University of Alabama at Birmingham, AL 35294, USA;bSkin Diseases Research Center, University of Alabama at Birmingham, AL 35294, USA;cDivision of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA |
| Abstract: | |
| Keywords: | Abbreviations: CsA, cyclosporine A TAK1, tumor growth factor β-activated kinase1 TAB1, TAK binding protein 1 NFκB, nuclear factor κB NMSC, non-melanoma skin cancer SCC, squamous cell carcinoma BCC, basal cell carcinoma UVB, ultraviolet B OTRs, organ transplant recipients MPP, mitochondrial permeability pore VEGF, vascular endothelial growth factor IκB, inhibitory κB IKKβ, IκB kinase β IRAK, interleukin-1 receptor associated kinase AMPK, AMP-activated protein kinase |
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