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Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung |
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| Authors: | Yoshida Yasunobu Yamashita Takuya Nagano Kazuya Imai Sunao Nabeshi Hiromi Yoshikawa Tomoaki Yoshioka Yasuo Abe Yasuhiro Kamada Haruhiko Tsutsumi Yasuo Tsunoda Shin-ichi |
| Affiliation: | aLaboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan;bDepartment of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan;cDepartment of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan;dThe Center of Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan |
| Abstract: | Lymphatic endothelial cells in tumors (T-LECs) are considered to have different characteristics from LECs in non-tumor tissues (N-LECs). However, differences between the two types have not been well analyzed at molecular level. In this report, we performed differential proteome analysis of T-LEC and N-LEC models prepared by cultivation of LECs in tumor conditioned medium. By expression profiling of identified proteins using tissue microarrays, reticulocalbin-1 was found to be expressed in clinical specimen-derived T-LECs and lung cancer cells but not N-LECs. It is suggested that reticulocalbin-1 may be an important molecule in understanding T-LEC function and control of lymphatic metastasis. |
| Keywords: | Tumor lymphatic endothelial cells Lymph node metastasis Proteomics Reticulocalbin-1 Lung cancer |
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