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Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity |
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| Authors: | Joan Villarroya Mari-Carmen Lara Beatriz Dorado Marta Garrido Elena García-Arumí Anna Meseguer Michio Hirano Maya R Vilà |
| Institution: | aInstitut de Recerca, Hospital Universitari de la Vall d’Hebron, Barcelona, Spain;bInstitut de Recerca l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;cDepartment of Neurology, Columbia University Medical Center, New York, NY, USA;dCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Spain;eUnitat de Biologia Cel·lular i Molecular, IMIM-Hospital del Mar, Barcelona, Spain |
| Abstract: | |
| Keywords: | Mitochondrial DNA siRNA Thymidine kinase 2 Mitochondrial depletion syndrome Respiratory chain |
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