Redd1 inhibits the invasiveness of non-small cell lung cancer cells |
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| Authors: | Jin Hyeon-Ok Seo Sung-Keum Woo Sang-Hyeok Kim Young-Sun Hong Sung-Eun Yi Jae-Youn Noh Woo-Chul Kim Eun-Kyu Lee Jin-Kyung Hong Seok-Il Choe Tae-Boo Park In-Chul |
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| Affiliation: | aDivision of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea;bLaboratory of Modulation of Radiobiological Responses, Korea Institute of Radiological and Medical Sciences, 215-4, Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea;cDepartment of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea;dDepartment of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea;eDepartment of Microbiological Engineering, Kon-Kuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea |
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| Abstract: | Redd1 acts as a negative regulator of mTOR in response to various stress conditions, but its specific physiological role is currently unclear. In the present study, we showed that Redd1 inhibits the invasive activity of non-small cell lung cancer (NSCLC) cells. Interestingly, expression of Redd1 was extremely low in H1299 cells displaying high invasiveness, compared with that in H460 cells with lower invasive activity. Overexpression of Redd1 inhibited the invasive activity of H1299 cells, while suppression with specific siRNAs enhanced the invasiveness of H460 cells. Knockdown of the mTOR downstream substrate, S6K, resulted in a decrease in the invasive property of H1299 cells. Our results provide preliminary evidence that Redd1 inhibits the invasive activity of NSCLC cells via suppression of the mTOR downstream pathway. |
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| Keywords: | Invasion Mammalian target of rapamycin Migration Redd1 S6K |
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