Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury |
| |
Authors: | Goto Hiromasa Nomiyama Takashi Mita Tomoya Yasunari Eisuke Azuma Kosuke Komiya Koji Arakawa Masayuki Jin Wen Long Kanazawa Akio Kawamori Ryuzo Fujitani Yoshio Hirose Takahisa Watada Hirotaka |
| |
Institution: | aDepartment of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan;bSportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan;cCenter for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan;dCenter for Beta Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan |
| |
Abstract: | Glucagon-like peptide-1 is a hormone secreted by L cells of the small intestine and stimulates glucose-dependent insulin response. Glucagon-like peptide-1 receptor agonists such as exendin-4 are currently used in type 2 diabetes, and considered to have beneficial effects on the cardiovascular system. To further elucidate the effect of glucagon-like peptide-1 receptor agonists on cardiovascular diseases, we investigated the effects of exendin-4 on intimal thickening after endothelial injury. Under continuous infusion of exendin-4 at 24 nmol/kg/day, C57BL/6 mice were subjected to endothelial denudation injury of the femoral artery. Treatment of mice with exendin-4 reduced neointimal formation at 4 weeks after arterial injury without altering body weight or various metabolic parameters. In addition, in vitro studies of isolated murine, rat and human aortic vascular smooth muscle cells showed the expression of GLP-1 receptor. The addition of 10 nM exendin-4 to cultured smooth muscle cells significantly reduced their proliferation induced by platelet-derived growth factor. Our results suggested that exendin-4 reduced intimal thickening after vascular injury at least in part by the suppression of platelet-derived growth factor-induced smooth muscle cells proliferation. |
| |
Keywords: | Glucagon-like peptide-1 Neointimal formation Type 2 diabetes Smooth muscle cells |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|