Hypoxia induces beta-amyloid in association with death of RGC-5 cells in culture |
| |
| Authors: | Li Juan Dong Zhizhang Liu Bingqian Zhuo Yehong Sun Xuerong Yang Zhikuan Ge Jian Tan Zhiqun |
| |
| Affiliation: | aState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;bDepartment of Neurology, University of California Irvine School of Medicine, Irvine, CA 92697, USA;cInstitute of Memory Impairments and Neurological Disorders, University of California Irvine School of Medicine, Irvine, CA 92697, USA |
| |
| Abstract: | Beta-amyloid (Aβ) derived from amyloid precursor protein (APP) has been associated with retinal degeneration in Alzheimer’s disease (AD) and glaucoma. This study examined whether hypoxia exposure induces Aβ accumulation in RGC-5 cells. While levels of APP mRNA and protein significantly increased in the cells, elevated abundance of Aβ was also observed in cells and culture medium between 12 or 24 and 48 h after 5% O2 hypoxia treatment. Additionally, there is a close relationship between induction of APP and Aβ and intracellular accumulation of ROS along with loss of mitochondrial membrane potential followed by the death of RGC-5 cells in culture under hypoxia. These results suggest a possible involvement of APP and Aβ in the death of RGCs challenged by hypoxia. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
