Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression |
| |
Authors: | Mahesh Radhakrishnan Jindal Ankur Gautam Baldev Bhatt Shvetank Pandey Dilip |
| |
Affiliation: | Department of Pharmacy, Birla Institute of Technology & Science, Pilani-333031, Rajasthan, India |
| |
Abstract: | Linezolid, an oxazolidinone class derivative is a reversible and nonselective inhibitor of monoamine oxidase (MAO), predominantly for MAO-A type. MAO-A is a key enzyme regulating the catabolism of catecholamine neurotransmitters in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression and inhibition of MAO-A level in the brain could be used to treat depression. Hence, the objective of this study was to evaluate the anti-depressant-like effect of linezolid, a MAO-A inhibitor in the animal models of depression. In the present study, linezolid (10 & 20 mg/kg, i.p.), exhibited anti-depressant-like effects in forced swim test (FST) and tail suspension test (TST) in mice without influencing the baseline locomotion. Moreover, linezolid (10 & 20 mg/kg, i.p.), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats. In conclusion, the behavioral investigation revealed the anti-depressant-like effect of linezolid in rodent’s behavioral model. |
| |
Keywords: | Linezolid Anti-depressant Monoamine oxidase inhibitor Behavioral test |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|