Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways |
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| Authors: | Su-Hwa Kim Hyun Cheol Bae Eun-Jung Park Chae Ryun Lee Byung-Joo Kim Sanghoon Lee Hyun Ho Park Sung-Joon Kim Insuk So Tae Woo Kim Ju-Hong Jeon |
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| Affiliation: | aDepartment of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea;bLaboratory of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul 136-701, Republic of Korea;cSchool of Korean Medicine, Pusan National University, Yangsan 626-770, Republic of Korea;dDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA;eSchool of Biotechnology, Yeungnam University, Gyeongsan 712-749, Republic of Korea;fInstitute of Dermatological Science, Seoul National University, Seoul, Republic of Korea |
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| Abstract: | The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer. |
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| Keywords: | Abbreviations: AIPC, androgen-independent prostate cancer CDK, cyclin-dependent kinase |
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