NO., CO and .OH. Endogenous soluble guanylyl cyclase-activating factors. |
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| Authors: | H H Schmidt |
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| Institution: | Northwestern University Medical School, Department of Pharmacology, Chicago, IL 60611. |
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| Abstract: | Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these are formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3',5'-monophosphate level. |
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