A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus |
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| Authors: | NorioAgata MichioOhta MasashiMori MinoruIsobe |
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| Institution: | Nagoya City Public Health Research Institute, 1-11 Hagiyamacho, Mizuho, Nagoya 467, Japan; Department of Bacteriology, Nagoya University School of Medicine, 65 Tsurumaicho, Showa, Nagoya 466, Japan; Laboratory of Organic Chemistry, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-01, Japan |
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| Abstract: | Abstract A vacuole-formation substance, cereulide of Bacillus cereus , is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus , a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells. |
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| Keywords: | Bacillus cereus Cereulide Emesis Suncus murinus HEp-2 cell Valinomycin |
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