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Patterns of cell proliferation and apoptosis by topographic region in normal Bos taurus vs. Bos indicus crossbreeds bovine placentae during pregnancy |
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| Authors: | Patricia R Facciotti Rose EG Rici Durvanei A Maria Marcelo Bertolini Carlos E Ambrósio Maria A Miglino |
| Affiliation: | 1. Department of Surgery, Faculty of Veterinary Medicine and Animal Science, S?o Paulo University, 05508-270, S?o Paulo, SP, Brazil 2. Biochemical and Biophysics Laboratory, Butantan Institute, 05503-900, S?o Paulo, Brazil 3. UDESC, School of Veterinary Medicine, Santa Catarina State University, 88520-000, Lages, Santa Catarina, Brazil 4. Department of Basic Science/FZEA, Faculty of Veterinary Medicine, S?o Paulo University, 13635-900, Pirassununga, SP, Brazil |
| Abstract: | BackgroundPlacental and fetal growth requires high rates of cellular turnover and differentiation, which contributes to conceptus development. The trophoblast has unique properties and a wide range of metabolic, endocrine and angiogenic functions, but the proliferative profile of the bovine placenta characterized by flow cytometry analysis and its role in fetal development are currently uncharacterized. Complete understanding of placental apoptotic and proliferative rates may be relevant to development, especially if related to the pathogenesis of pregnancy losses and placental abnormalities. |
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