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Chromosomal localization of three human genes encoding bone morphogenetic protein receptors |
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| Authors: | Anna-Karin Åström Donald Jin Takeshi Imamura Eva Röijer Bradley Rosenzweig Kohei Miyazono Peter ten Dijke Göran Stenman |
| Institution: | Laboratory of Cancer Genetics, Department of Pathology, G?teborg University, Sahlgrenska University Hospital, SE-413 45 G?teborg, Sweden, SE Creative Biomolecules Inc., 45 South Street, Hopkinton, Massachusetts 01748, USA, US Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, Kami-ikebukuro, Toshima-ku, Tokyo 170, Japan, JP Amgen, 3200 Walnut Street, Boulder, Colorado 80301, USA, US Ludwig Institute for Cancer Research, Biomedical Center, Box 595, SE-751 24 Uppsala, Sweden, SE |
| Abstract: | Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that play a pivotal role in bone formation during embryogenesis and fracture repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinase complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR-II). BMPR-IA and IB are closely related receptors, with sequence differences conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes. Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23. Received: 17 February 1997 / Accepted: 15 October 1998 |
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